*40 MEDICAL CASES RELATING SEIZURES/EPILEPSY TO VACCINES: Barkin - TopicsExpress



          

*40 MEDICAL CASES RELATING SEIZURES/EPILEPSY TO VACCINES: Barkin RM, Jabhour JT, Samuelson J S, "Immunizations, seizures, and subsequent evaluation," JAMA 1987 Jul 10;258(2):201. Baraff LJ et al (1988). Infants and children with convulsions and hypotonic-hyporesponsive episodes following diphtheria-tetanus-pertussis immunization: follow-up evaluation. Pediatrics 81(6):789-94 1988. Department of Pediatrics, University of California, Los Angeles, School of Medicine. In a prior prospective study, we evaluated the nature and rates of adverse reactions occurring within 48 hours following 15,752 diphtheria-tetanus-pertussis (DTP) immunizations. Nine children had convulsions, and nine had hypotonic-hyporesponsive episodes... No child had significant neurologic deficit, although four had minor neurologic abnormalities... Blumberg DA, "Severe reactions associated with diphtheria-tetanus-pertussis vaccine: detailed study of children with seizures, hypotonic-hypo-responsive episodes, high fevers, and persistent crying."Pediatrics 1993 Jun; 91(6):1158-1165. Buchwald G. [See Related Articles] [Convulsive disease recognized by a court decision as a vaccination injury following smallpox vaccination]. Med Welt. 1967 Jun 17;24:1488-91. German. No abstract available.PMID: 4389310; UI: 69226516. Cizewska S, Huber Z, Sluzewski W, "[Prophylactic inoculations and seizure activity in the EEG]," Neurol Neurochir Pol 1981 Sep-Dec;15(5-6):553-557. [Article in Polish] Coplan J, "Seizures following immunizations," J Pediatr 1983 Sep;103(3):496. Cherry JD et al (1993). Pertussis immunization and characteristics related to first seizures in infants and children. J Pediatr 122(6):900-3 1993. Department of Pediatrics, University of California Los Angeles School of Medicine. In a previous study in which we examined the relationship of pertussis immunization to the onset of neurologic disorders during 1967 and 1968 and during 1972 and 1973 in Denmark, there were 554 children with initial onset of epilepsy and 2158 children with first febrile convulsions... The cause of increased severity of febrile seizures apparently associated with pertussis immunization is unknown. Griffin MR, et al (1991) Risk of seizures after measles-mumps-rubella immunization. Pediatrics. 1991 Nov;88(5):881-5. PMID: 1945626; UI: 92051053. To evaluate the risks of seizures and other neurologic events following measles-mumps-rubella (MMR) or measles-rubella (MR) immunization, a retrospective cohort study was conducted among 18,364 Tennessee children enrolled in Medicaid who received MMR or MR immunizations in their first 3 years of life. One hundred children had seizures at some time between immunization and 36 months; there were no encephalopathies during this period. Four children had febrile seizures in the 7 through 14 days following MMR or MR immunization compared with 72 in the interval 30 or more days following MMR or MR immunization yielding a relative risk (95% confidence interval) of 2.1 (0.7 to 6.4). Although not statistically significant, this increase in febrile seizures in the 7-through 14-day interval following MMR immunization is coincident with the occurrence of fever following MMR immunization and is consistent with reports of other investigators. Griffin MR et al. Risk of seizures and encephalopathy after immunization with the diphtheria-tetanus-pertussis vaccine. JAMA 263(12):1641-5 1990. Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tenn 37232-2637. We evaluated the risks of seizures and other neurological events following diphtheria-tetanus-pertussis (DTP) immunization for 38,171 Tennessee Medicaid children who received 107,154 DTP immunizations in their first 3 years of life. There were 2 children with encephalitis; both had disease onset more than 2 weeks following DTP immunization. There were 277 children who had febrile seizures, 42 with afebrile seizures, and 37 with seizures associated with other acute neurological illness (acute symptomatic). The risk of febrile seizures in the 0 to 3 days following DTP immunization (n = 6) was 1.5 (95% confidence interval, 0.6 to 3.3) times that of the control period 30 or more days following DTP immunization... Huttenlocher PR, Hapke RJ, "A follow-up study of intractable seizures in childhood." Ann Neurol 1990 Nov; 28(5):699-705. Hirtz DG, Nelson KB, Ellenberg J H, "Seizures following childhood immunizations", Pediatr 1983 Jan; 102(1):14- 18. Jacobson V et al (1988). Relationship of pertussis immunization to the onset of epilepsy, febrile convulsions and central nervous system infections: a retrospective epidemiologic study. Tokai J Exp Clin Med 13 Suppl:137-42 1988. Department of Neurology, UCLA School of Medicine. A change in the pertussis immunization schedule in Denmark allowed a retrospective study examining the relationship of the time of onset of selected neurologic disorders with the time of pertussis immunization in two core cohorts of children. Records of 2,199 children with febrile seizures were reviewed and a significant association between first febrile seizures and the scheduled age of pertussis immunization was noted (p = 0.004)... Jensen KG, et al. [See Related Articles] [Acute-convulsive reactions following smallpox vaccination]. Med Welt. 1971 Oct 22;43:1702-5. German. No abstract available.PMID: 5132712; UI: 72077108. Miller CL. Convulsions after measles vaccination. Lancet. 1983 Jul 23;2(8343):215. No abstract available.PMID: 6135043; UI: 83243659.[See Related Articles] Murphy, J.V., Sarff, L.D., Marquardt, K.M.; Recurrent Seizures after Diphtheria, Tetanus, and Pertussis Vaccine Immunization; AJDC, Vol 138, Oct 1984; 908-911 Twenty-two patients with recurrent seizures that started less than 24 hours after immunisation with diphtheria, tetanus and pertussis (DTP) vaccine were retrospectively studied. The initial seizure generally occurred after one of the first three DTP vaccine immunisations, and followed that immunisation by less than 12 hours. Two of the 22 patients were siblings. Eight patients had additional immunisations with DTP vaccine and four had immediate worsening of their seizures. Of the 22 patients, only one was seizure free and stopped taking anticonvulsants. Three patients exhibited normal development and 11 had severe developmental delays. Based on these observations, we reviewed current contraindications for immunisation with pertussis vaccine. Stetler, H.C., Orenstein, W.A., Bart, K.J., Brink, E.W., Brennan, JP, Hinman, A.R.; History of convulsions and use of pertussis vaccine; Journal of Pediatrics; 1985; 107:175-179 Data on 2062 reports from the Monitoring System for Adverse Events Following Immunisation, Centres for Disease Control (CDC) were analysed to compare the risk of a personal or family history of convulsions in children who had a neurologic adverse event after receipt of diphtheria-tetanus-pertussis (DTP) vaccine with those who had a nonneurologic adverse event. Children with a neurologic event after DTP vaccine had a 7.2 times higher risk for personal history of convulsions (95% confidence limits 4.5 to 11.5) and a 4.5 times higher risk for family history of convulsions (95% confidence limits 3.1 to 6.7) than did children with an adverse event that did not affect the nervous system. Children with either a febrile or nonfebrile convulsion after receipt of DTP were significantly more likely to have a personal history of convulsions that children with a nonneurologic adverse event (P
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