Different Strokes for Different Folks. Do you love maliciously depriving others life saving heart medication severely neglecting severely abusing severely terrorized financial extorting destroying lives and murdering them? Do you love giving those with heart conditions blood pressures ranging 35/38 424/375 so they will have strokes? We sure dont! We love being able to help those suffering with serious heart conditions (congestive heart failure) dopamine deficiency and (acute heart failure) severe dopamine deficiency/deprivation. Those suffering with dopamine deficiency do not have the ability to produce enough dopamine in their body. We love successful government prevention-management programs/programs with ongoing successful results that greatly improves the quality of life of others. Many people are severely suffering from dopamine deficiency. Dopamine beta-hydroxylase deficiency On this page: Description Genetic changes Inheritance Diagnosis Additional information Other names Glossary definitions Reviewed September 2008 What is dopamine beta-hydroxylase deficiency? Dopamine beta (β)-hydroxylase deficiency is a condition that affects the autonomic nervous system, which controls involuntary body processes such as the regulation of blood pressure and body temperature. Problems related to this disorder can first appear during infancy. Early signs and symptoms may include episodes of vomiting, dehydration, decreased blood pressure (hypotension), difficulty maintaining body temperature, and low blood sugar (hypoglycemia). Individuals with dopamine β-hydroxylase deficiency typically experience a sharp drop in blood pressure upon standing (orthostatic hypotension), which can cause dizziness, blurred vision, or fainting. This sudden drop in blood pressure is usually more severe when getting out of bed in the morning, during hot weather, and as a person gets older. People with dopamine β-hydroxylase deficiency experience extreme fatigue during exercise (exercise intolerance) due to their problems maintaining a normal blood pressure. Other features of dopamine β-hydroxylase deficiency include droopy eyelids (ptosis), nasal congestion, and an inability to stand for a prolonged period of time. What genes are related to dopamine beta-hydroxylase deficiency? Mutations in the DBH gene cause dopamine β-hydroxylase deficiency. The DBH gene provides instructions for producing the enzyme dopamine β-hydroxylase. This enzyme converts dopamine to norepinephrine, both of which are chemical messengers (neurotransmitters) that transmit signals between nerve cells. DBH gene mutations result in the production of a nonfunctional dopamine β-hydroxylase enzyme. People who lack functional dopamine β-hydroxylase cannot convert dopamine to norepinephrine, which leads to a shortage of norepinephrine in the body. The lack of norepinephrine causes difficulty with regulating blood pressure and other autonomic nervous system problems seen in dopamine β-hydroxylase deficiency. Read more about the DBH gene. How do people inherit dopamine beta-hydroxylase deficiency? This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition. Where can I find information about diagnosis or management of dopamine beta-hydroxylase deficiency? These resources address the diagnosis or management of dopamine beta-hydroxylase deficiency and may include treatment providers. Gene Review: Dopamine Beta-Hydroxylase DeficiencyThis link leads to a site outside Genetics Home Reference. Genetic Testing Registry: Dopamine beta hydroxylase deficiencyThis link leads to a site outside Genetics Home Reference. Vanderbilt Autonomic Dysfunction CenterThis link leads to a site outside Genetics Home Reference. You might also find information on the diagnosis or management of dopamine beta-hydroxylase deficiency in Educational resources and Patient support. General information about the diagnosis and management of genetic conditions is available in the Handbook. Read more about genetic testing, particularly the difference between clinical tests and research tests. To locate a healthcare provider, see How can I find a genetics professional in my area? in the Handbook. Where can I find additional information about dopamine beta-hydroxylase deficiency? You may find the following resources about dopamine beta-hydroxylase deficiency helpful. These materials are written for the general public. MedlinePlusThis link leads to a site outside Genetics Home Reference. - Health information Additional NIH Resources - National Institutes of Health National Institute of Neurological Disorders and Stroke: Dysautonomia Information PageThis link leads to a site outside Genetics Home Reference. Educational resources - Information pages (7 links) Patient support - For patients and families (2 links) You may also be interested in these resources, which are designed for healthcare professionals and researchers. Gene ReviewsThis link leads to a site outside Genetics Home Reference. - Clinical summary Genetic Testing Registry - Repository of genetic test information (1 link) ClinicalTrials.govThis link leads to a site outside Genetics Home Reference. - Linking patients to medical research PubMedThis link leads to a site outside Genetics Home Reference. - Recent literature OMIMThis link leads to a site outside Genetics Home Reference. - Genetic disorder catalog What other names do people use for dopamine beta-hydroxylase deficiency? dopamine β-hydroxylase noradrenaline deficiency norepinephrine deficiency For more information about naming genetic conditions, see the Genetics Home Reference Condition Naming Guidelines and How are genetic conditions and genes named? in the Handbook. What if I still have specific questions about dopamine beta-hydroxylase deficiency? Ask the Genetic and Rare Diseases Information CenterThis link leads to a site outside Genetics Home Reference.. Where can I find general information about genetic conditions? The Handbook provides basic information about genetics in clear language. What does it mean if a disorder seems to run in my family? What are the different ways in which a genetic condition can be inherited? If a genetic disorder runs in my family, what are the chances that my children will have the condition? Why are some genetic conditions more common in particular ethnic groups? These links provide additional genetics resources that may be useful. Genetics and Health Resources for Patients and Families Resources for Health Professionals What glossary definitions help with understanding dopamine beta-hydroxylase deficiency? autonomic nervous system ; autosomal ; autosomal recessive ; cell ; deficiency ; dehydration ; dopamine ; enzyme ; fainting ; gene ; hypermobility ; hypoglycemia ; hypotension ; inherited ; involuntary ; joint ; nervous system ; neurotransmitters ; orthostatic ; ptosis ; recessive ; semen You may find definitions for these and many other terms in the Genetics Home Reference Glossary. See also Understanding Medical Terminology. References (6 links) The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.
Posted on: Sat, 06 Dec 2014 11:26:30 +0000
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