Genetic Loss Or Pharmacological Blockade Of Testes Taste Receptors Causes Male Sterility - TAS1R taste receptors and their associated heterotrimeric G protein gustducin are involved in sugar and amino acid sensing in taste cells and in the gastrointestinal tract. They are also strongly expressed in testis and sperm, but their functions in these tissues were previously unknown. Using mouse models, researchers show that the genetic absence of both TAS1R3, a component of sweet and amino acid taste receptors, and the gustducin α-subunit GNAT3 leads to male-specific sterility.
Posted on: Tue, 02 Jul 2013 12:40:14 +0000
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