*** Post-doc position available *** In: Aalborg, Denmark Theme: Interaction between calmodulin and ryanodine receptors 3-years Postdoctoral position at Aalborg University, Denmark. A postdoctoral position is available at the Department of Biotechnology, Chemistry and Environmental Engineering of Aalborg University, Aalborg, Denmark. en.bio.aau.dk The position is available for three years, starting from November 1st, 2013 or as soon as possible thereafter. Calmodulin (CaM) is the universal intracellular calcium sensor and mediator of calcium signaling. Among many other processes, CaM is also regulates the contraction of muscles through interaction with the ryanodine receptors 1 (skeletal muscle) and 2 (cardiac muscle). Recently, mutations of CaM having a specific impact on heart rhythm were identified (Nyegaard et al., 2012). Their impact is similar to that of mutations in the cardiac ryanodine receptor 2 (RyR2) ) (Priori et al., 2001), but not in the skeletal ryanodine receptor (RyR1). With this project, we want to investigate the biochemical, thermodynamic and structural details of the interaction between CaM and RyR1&2 by NMR spectroscopy, and we want to investigate the influence of mutations on the structural dynamics of CaM in presence and absence of ligand by paramagnetic relaxation enhanced NMR. The successful candidate will have a strong background in protein expression/purification, and ideally also be experienced in protein NMR spectroscopy, or at least interested in learning protein NMR spectroscopy. Contact: Reinhard Wimmer ([email protected]) or Michael T. Overgaard ([email protected]) by sending your CV, your list of publications and names of 2-3 reference persons. References Nyegaard, M., Overgaard, M. T., Søndergaard, M. T., Vranas, M., Behr, E. R., Hildebrandt, L. L., Lund, J., et al. (2012). Mutations in Calmodulin Cause Ventricular Tachycardia and Sudden Cardiac Death. Am. J. Hum. Genet., 91(4), 703–712. doi:10.1016/j.ajhg.2012.08.015 Priori, S. G., Napolitano, C., Tiso, N., Memmi, M., Vignati, G., Bloise, R., Sorrentino, V., et al. (2001). Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia. Circulation, 103(2), 196–200.
Posted on: Sun, 15 Sep 2013 10:50:28 +0000
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