The AACT toxicology question of the day for today: Acrylamide (ACR) is a water-soluble alkene used in the production of a variety of commercial polymers and gels. Polyacrylamide compounds are often used in the cosmetic, paper, and textile industries; in ore processing; and as soil conditioners and flocculants for wastewater treatment. During the 1950s it became apparent that occupational exposure to ACR had the potential to cause toxicity. Which organ system is involved and what characterizes the toxicity associated with ACR? Scroll down for the answer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . High-level, long duration, occupational ACR exposure has the potential, in some cases, to cause a neurotoxic syndrome characterized by ataxia, skeletal muscle weakness, cognitive impairment, and numbness of the extremities. (LoPachin RM and Gavin T. Molecular mechanism of acrylamide neurotoxicity: Lessons learned from organic chemistry. 2012 Env Health Perspect 120:1650-1657)
Posted on: Mon, 31 Mar 2014 23:29:09 +0000
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