e see my DTN FORMULA---PREVENTION OF SICKLE CELL DISEASE AND OTHER HAEMOGLOBINOPATHIES BY DTN FORMULA OF GENETIC COUNSELING Hemoglobinopathy Hemoglobinopathy is a kind of genetic defect that results in abnormal structure of one of the globin chains of the hemoglobin molecule.[1]Hemoglobinopathies are inherited single-gene disorders; in most cases, they are inherited as autosomal co-dominant traits.[2] Common hemoglobinopathies include sickle-cell disease. It is estimated that 7% of worlds population (420 million) are carriers, with 60% of total and 70% pathological being in Africa. Hemoglobinopathies are most common in ethnic populations from Africa, the Mediterranean basin and Southeast Asia. Hemoglobin Variants[edit] • Hb S • Hb C • Hb E • Hb D-Punjab • Hb O-Arab • Hb G-Philadelphia • Hb Constant Spring • Hb Hasharon • Hb Korle-Bu • Hb Lepore • Hb M • Hb Kansas (β102 Asn>Thr)[6] Either hemoglobinopathy or thalassemia, or both, may cause anemia. Some well-known hemoglobin variants such as sickle-cell anemia andcongenital dyserythropoietic anemia are responsible for diseases, and are considered hemoglobinopathies. However, many hemoglobin variants do not cause pathology or anemia, and thus are often not classed as hemoglobinopathies, because they are not considered pathologies. Hemoglobin variants are a part of the normal embryonic and fetal development, but may also be pathologic mutant forms of hemoglobin in a population, caused by variations in genetics. Other variants cause no detectable pathology, and are thus considered non-pathological variants.[4][5] All the Haemoglobinopathies and Thalassaemia will be eliminated from the affected countries of the WORLD if DTN formula will be adopted. DTN FORMULA 1st step- BLOOD WILL BE EXAMINED FOR Hb.Electrophoresis by HPLC method IN THE PRE- MARITAL AGE.GROUP. -2nd-THE RESULT OF EXAMINATION WILL DIVIDE THE SOCIETY IN TO 3 GROUPS- RESULT----- SHORTLY KNOWN AS 1. DISEASE ------------------ D 2. TRAIT ----------------------- T 3. NORMAL ------------------- N MARRIAGE WILL BE ALLOWED OR DISALLOWED IN THE FOLLOWING MANNER D + D - NO D + T - NO T + T - NO AND D + N - YES T + N - YES N + N - YES GENETIC EXPLANATION TO THE FORMULA --------- EACH HUMAN GENE HAS ONE HALF GENE FROM MOTHER AND OTHER FROM FATHER D ------------- SS---(SICKLE GENE FROM BOTH PARENTS) T -------------- AS--(NORMAL GENE FROM ONE PARENT SICKLE GENE FROM OTHER) N -------------- AA-(NORMAL GENE FROM BOTH PARENTS) D + D SS SS SS SS SS SS D + T SS AS AS SS AS SS T + T AS AS AA SS AS AS THIS IS HAPPENING IN THE INNOCENT RACES WITHOUT THEIR KNOWLEDGE FOR THE LAST HUNDREDS OF YEARS. HENCE PLENTY OF SS OR DISEASE CASES IN THE SOCIETY. IF THE DTN FORMULA WILL BE ADOPTED ---- D + N SS AA AS AS AS AS T + N AS AA AA AS AA AS N + N AA AA AA AA AA AA NOT A SINGLE SS OR DISEASE CASE WILL APPEAR IN THE SOCIETY. LET US JOIN OUR HANDS TO SAVE THE NEXT GENERATION FROM DREADED “DISEASE” CASES. TO ELABORATE MORE DISEASE CASES ARE ABOUT 0.1% AND TRAIT CASES ARE ABOUT 7-10% IN THE SOCIETY. HENCE FOR GENETIC COUNSELING WE GET 90% NORMAL CASES. WE SHOULD NOT BE PANIC AND LET US PROCEED FOR EXAMINATION OF BLOOD FOR HB-ELECTROPHORESIS BEFORE MARRIAGE. OUR TARGET IS THE PRE-MARRITAL AGEGROUP. TAKE A VOW THAT EACH COUPLE IS TO ADOPT DTN FORMULA. SPECIAL ATTENTION TO BE GIVEN FOR EXCLUSION OF THALASSAEMIA AND G-6-PD DIFICIENCY ALSO
Posted on: Tue, 04 Mar 2014 14:54:33 +0000
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