A very informative web site provided by #Genentech that discusses the various #HER Family receptors (HER-1, HER-2, HER-3, and HER-4), their interactions with each other, and their roles in #cancer. HER-2 and HER-3 interact to form a complex that hyper-activates signaling downstream, that results in an aggressive cancer. When #HER2 is targeted using a specific inhibitor, like #Herceptin (#trastuzumab), the tumor cells can compensate by up-regulating HER3 activation, making it more difficult to reverse the process of HER2:HER3 hyper-activation. HER3 does not remain “turned off” after inhibitor #treatment and is able to be activated, which allows for activation of the PI3K/Akt pathway, the pathway that modulates a variety of cancer-related processes including proliferation, cell death, and cell survival. Thus, it is important to have information related to the HER status in each individual tumor. #TheranosticsHealth #theranostics #personalizedmedicine #breastcancer #proteomics #diagnostics #diagnostic #signaltransduction #egfr #test biooncology/research-education/her/dimer
Posted on: Fri, 30 Aug 2013 13:45:07 +0000
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