Alabama Association of Nursing StudentsGraduate Nursing at The University of AlabamaUAB School of NursingPediatric NursingUAB School of Nursing Honors in Nursing Program UAB Comprehensive Cancer Center UAB Hospital Nursing UAB Student Nurses AssociationCampus Ministry Association at UAB UAB Center for Palliative and Supportive Care UAB Wellness UAB School of Medicine UAB Medicine Magazine UAB Magazine UAB Medicine UAB Women & Infants Services UAB School of Public Health UAB Undergraduate Research UAB Cancer Biology PhD Program UAB Student Life UAB NewsYoung Supporters Board of the UAB Comprehensive Cancer Center UAB Service Learning UAB College of Arts & Sciences UAB School of Health Professions UAB Support Team Network Uab Alphas UAB - The University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) Undergraduate Admission Page Uab SophSteel Magnolias breast cancer support groupAmerican Cancer Society of North Central AlabamaBreast Cancer Research Foundation of AlabamaAmerican Cancer Society Cancer Action Network Mississippi - ACS CANMaking Strides Against Breast Cancer of South AlabamaNational Cervical Cancer Coalition-Alabama ChapterAmerican Cancer Society Cancer Action Network Alabama - ACS CAN Cancer Support Community East Tennessee Cancer Care Center of TuscaloosaAmerican Cancer Society - Huntsville/Madison CountyAmerican Cancer Society - BirminghamNorma Livingston Ovarian Cancer FoundationPassion for Pink- Breast Cancer AwarenessGeorgia Breast Cancer CoalitionTennessee Breast Cancer CoalitionAmerican Cancer Society - AtlantaAmerican Cancer Society - ChattanoogaGadsden Regional Cancer CenterNortheast Alabama Regional Medical Center Regs Coffee House Fan PageMontgomery Cancer CenterAlabama Ovarian Cancer Alliance Sean D. McAllister, PhD cpmc.org/professionals/research/programs/science/sean.html Pierre Desprez, PhD cpmc.org/professionals/research/programs/science/desprez.html ...our studies have identified Id-1 as a critical regulator of breast cancer progression and suggest the feasibility of developing novel therapeutic approaches to target Id-1 expression to reduce breast cancer metastasis in humans. pnas.org/content/100/23/13543 Recent Research on Cannabinoids. We targeted breast cancer cells that expressed high amounts of the protein Id-1. CBD is highly effective at turning off this specific gene that controls breast cancer metastasis. cpmc.org/professionals/research/programs/science/cannabidiolarticles.html Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Our data demonstrate the efficacy of CBD in pre-clinical models of breast cancer. CBD inhibits human breast cancer cell proliferation and invasion. The results have the potential to lead to the development of novel non-toxic compounds for the treatment of breast cancer... ncbi.nlm.nih.gov/pmc/articles/PMC3410650/ Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells...CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic breast cancer cells leading to the down-regulation of tumor aggressiveness...reducing Id-1 expression with cannabinoids could also provide a therapeutic strategy for the treatment of additional aggressive cancers because Id-1 expression was found to be up-regulated during the progression of almost all types... mct.aacrjournals.org/content/6/11/2921.long Id-1 is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target...our results establish Id-1 as a key regulator of both invasion and stemness in GBM cells and demonstrate that the non-toxic cannabinoid compound CBD down-regulates Id-1 expression and tumor aggressiveness in culture and in vivo. ncbi.nlm.nih.gov/pmc/articles/PMC3594064/
Posted on: Fri, 27 Jun 2014 18:20:36 +0000
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