Analysis from Brown and Harvard suggest that there were two strain of virus of Ebola at the same time in Sierra Leone. Still inconclusive data in original natural reservoir Our data suggest that the Sierra Leone outbreak stemmed from the introduction of two genetically distinct viruses from Guinea around the same time. Samples from 12 of the first EVD patients in Sierra Leone, all believed to have attended the funeral of an EVD case from Guinea, fall into two distinct clusters (clusters 1 and 2) (Fig. 4A and fig. S8). Molecular dating places the divergence of these two lineages in late April (Fig. 3B), predating their co-appearance in Sierra Leone in late May (Fig. 4B); this finding suggests that the funeral attendees were most likely infected by two lineages then circulating in Guinea, possibly at the funeral (fig. S9). All subsequent diversity in Sierra Leone accumulated on the background of those two lineages (Fig. 4A), consistent with epidemiological information from tracing contacts. sciencemag.org/content/345/6202/1369/F1.expansion.html Note that this study was done on over 70% of the Ebola patient in Kenema.
Posted on: Mon, 29 Sep 2014 07:24:09 +0000
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