Anti-Cancer Betulinic acid, a constituent of Chaga, is cytotoxic and triggers apoptosis through a direct effect on the mitochondria of cancer cells. Other apoptosis-inducing factors result in cleavage of caspases and nuclear fragmentation. Like many medicinal mushrooms, Chaga is rich in beta glucans, which have immunomodulating activities. Beta glucans bind to Complement Receptor 3 (CR3) that allows the immune cells to recognize cancer cells as “non-self” A hot water extract of Chaga exhibited inhibitory and proapoptotic actions against colon cancer cell proliferation via up-regulation of Bax and caspase-3 and down-regulation of Bcl-2. For more information on betulinic acid, please go to our Science & Research Tab and read the following Elsevier Bioorganic & Medicinal Chemistry Letters on New ionic derivatives of betulinic acid as highly potent anti-cancer agents, Memorial Sloan-Kettering Cancer Center, and Developing Novel Derivatives of Betulinic Acid for Fighting HIV. In addition to being used as an anti-cancer, Chaga has demonstrated anti-HIV, antibacterial, anti-malarial, anti-inflammatory and anthelmintic properties. Chaga is also antiviral, antifungal, antimicrobial and anti-Candida. Chaga is an immune system modulator as well as an adaptogen and has the highest level of superoxide dismutase or (SOD) detected in any food or herb in the world.
Posted on: Sat, 15 Mar 2014 15:43:24 +0000
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