Aromatase inhibitor acting by increasing km value Case - TopicsExpress

Aromatase inhibitor acting by increasing km value Case details An 8-year-old girl presents with precocious puberty, short stature, and coffee colored macules. The patient is diagnosed with McCune-Albright syndrome that results from estrogen production due to excessive Aromatase activity from ovarian follicular cysts. To treat the precocious puberty and other symptoms, the patient is prescribed with a drug that inhibits the Aromatase activity. The drug is known to act by binding the substrate binding site, producing an increase in km. Which of the following choices best describes the mechanism of inhibition of this drug? A. Competitive B. Non Competitive C. Allosteric D. Suicidal E. Feedback inhibition

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