As any of you know, Ruben and I took a beautiful but very difficult 4 hour hike up into the mountains. We never did make it to the top. On the return, I fell and really jacked up my arm. I have been trying hard to get it healed. My PT insisted that I take CARTIGEN. Below is the printout about it. In five days I have had terrific relief. I hope that you with aches and pains take a look. If you know anything extra about it, please post. Best Wishes, jc INFORMATION TO PRESCRIBE WIDE I. BRAND NAME. CARTIGEN NF® II. GENERIC NAME. Chondroitin - DIACEREINA III. PHARMACEUTICAL FORM AND FORMULATION. Tablets each tablet contains: sodium chondroitin sulfate. Diacereina. Excipient CBP. IV. Therapeutic indications. 600.00 Mg 50.00 mg 1 tablet CARTIGEN NF ® is indicated for the long-term treatment of pain and inflammation of rheumatoid arthritis, osteoarthritis, and/or degenerative joint disease and related diseases. V. pharmacokinetics and pharmacodynamics. The utility of the combination therapy of CARTIGEN NF® has as purpose restore metabolic balance of the articular cartilage, in addition to inhibiting the release of enzymes that degrade the articular cartilage as well as inhibit cytokines proinflamatorlas. The properties of the antiartrosicas diacereina are due to its ability to inhibit cytokines pro-inflammatory and pro- catabolic as interleukin - I, which plays an important role in the degradation of the articular cartilage, as well as in the inhibition of the production and release of enzymes that degrade the cartilage (collagenase and stromelysin). Chondroitin sulfate is one of the major constituents of the cartilage and has an exceptional ability to absorb water. The results of this feature that ensure the mechanical function of the elastic cartilage. In the course of the interphalangeal osteoarthritic degenerative processes, a decrease of the chondroitin contained in the cartilage has been observed, causing a specific enzymatic lysis. This leads to a low water-holding capacity, progressive of the joints. Diacereina. The Diacereina is a derivative of the anthraquinone which has been used in musculoskeletal disorders and joints as an inhibitor of interleukin-1. Interleukin-1 is a factor in the response of macrophages - neutrophils inflammation and plays a dominant role. This factor along with TNF (Tumor Necrosis Factor) and colony-stimulating factors produces a retraction mechanism that begins with inflammation of the tissue, along with the formation of leukocytes. After oral administration of Diacereina, this has an effect first-pass hepatic desacetilada and is becoming so total in the form of queen. The simultaneous ingestion with food causes a delay in absorption and prolongs the t max and at the same time increases its bioavailability. The Queen does not conjugate binds to the molecules of plasma in a 99 %, the half-life in plasma is 5 to 7 hours. The excretion is via the kidney in the form of queen and conjugate of glucuronidated and sulfates. Different studies have shown that the Diacereina: inhibits the production of interleukin 1, and decreases the collagenolytic activity. Among those. The properties of the antiartrosicas Diacereina are due to its ability to inhibit cytokines pro-inflammatory and pro- catabolic as interleukin - I, which plays an important role in the degradation of the articular cartilage, as well as in the inhibition of the production and release of enzymes that degrade the cartilage (collagenase and stromelysin). Chondroitin sulphate. Chondroitin: Chondroitin sulfate is one of the main components of the cartilage, characterized by its ability to secure water, function that allows you to secure the functional properties and mechanisms of the elastic cartilage. In the degenerative processes artrósicos pains due to the action of lytic enzymes are experiencing a loss of power to retain water, a progressive degeneration of the cartilage and a deterioration of the articular functioning. The administration of chondroitin produces a restoration of the balance of cartilage headphones with the improvement or disappearance of joint pains. Pharmacokinetics: The bioavailability of the chondroitin was studied in both animals and man. In humans reaches peak plasma after 5 to 6 hours, observing in parallel an increase in the rates of chondroitin sulphate in the synovial fluid. After the administration of 600 mg the maximum plasma concentration is 2.7 mcg/ml with a plasma half-life of 8.5 hours. VI. CONTRAINDICATIONS. Hypersensitivity to Diacereina and/or derivatives of anthraquinone or chondroitin or any of the excipient
Posted on: Sun, 09 Nov 2014 00:20:15 +0000
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