BioSmart Fact File 264.1 orbitbiotech biosmartworld Key - TopicsExpress

BioSmart Fact File 264.1 orbitbiotech biosmartworld Key regulator of colon cancer discovered A team headed by Angel R. Nebreda at the Institute for Research in Biomedicine (IRB) identifies a dual role of the p38 protein in colon cancer. The study demonstrates that, on the one hand, p38 is important for the optimal maintenance of the epithelial barrier that protects the intestine against toxic agents, thus contributing to decreased tumor development. Intriguingly, on the other hand, once a tumor has formed, p38 is required for the survival and proliferation of colon cancer cells, thus favoring tumor growth. The study is published today in Cancer Cell, a journal with one of the highest impact factors in cancer research.

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