Can synthesis deliver? Palmerolides are a family of Antarctic - TopicsExpress

Can synthesis deliver? Palmerolides are a family of Antarctic marine natural products, many of which display potent and selective cytotoxicity against melanoma cells. The confluence of promising bioactivities, limited natural supplies, and complex structures makes these compounds exciting targets for chemical synthesis. In their Review article, now available on Early View, M. Lisboa and G. Dudley, Florida State University, USA, discuss recent advances in the syntheses of these compounds with the hope that a more concise approach will further unlock their chemotherapeutic potential: bit.ly/HxvqJb

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