Cardinal signs of Acute Inflammation 1. Rubor (redness) and - TopicsExpress

Cardinal signs of Acute Inflammation 1. Rubor (redness) and calor (heat) • Due to histamine-mediated vasodilation of arterioles 2. Tumor (swelling) a. Due to a histamine-mediated increase in venular permeability b. Synonymous with edema, which refers to increased fluid in the interstitial space 3. Dolor (pain) • Prostaglandin E2 (PGE2) sensitizes specialized nerve endings to the effects of bradykinin and other pain mediators. 4. Functio laesa (loss of function)

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