Combination of Cognitive Therapy (CT) and AntiDepressant Medication (ADM) better recovery in patients with severe, nonchronic major depressive disorder (MDD). The most common treatment for depression, antidepressants are particularly recommended for patients with severe forms of the disorder. One third of patients achieve remission with any given ADM, half of these patients relapse during continuation treatment before achieving recovery. Simply reducing depressive symptoms is not enough and that full remission should be the goal of acute treatment. CT is as effective as antidepressants alone and that combining the 2 increases response rates. CT engages different mechanisms than ADM but that it likely does so only in some patients. Identifying these mechanisms may suggest ways to enhance treatment response. Future combinatorial trials should include comparisons with CT alone to examine the viability of each monotherapy, especially given evidence that CT effects persist beyond the end of treatment. MDD is one of the worlds great public health problems and the combination of psychotherapy and pharmacotherapy has long been advocated as a preferred approach to optimize outcomes. Steven D. Hollon, PhD, Vanderbilt University in Nashville, Tennessee, published online August 20, 2014. JAMA Psychiatry.
Posted on: Fri, 22 Aug 2014 01:09:57 +0000
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