Combining cell replication blocker with common cancer drug kills resistant tumor cells Researchers have found that an agent that inhibits mitochondrial division can overcome tumor cell resistance to a commonly used cancer drug, and that the combination of the 2 induces rapid and synergistic cell death. Separately, neither had an effect. The researchers blocked Drp1 in breast cancer cell lines with an agent called mitochondrial division inhibitor-1 (mdivi-1) and found that when mdivi-1 and the cancer drug cisplatin were given together, they caused DNA damage, DNA replication stress, and greater than expected apoptosis rates. >>The synergistic drug combo acted through 2 independent biochemical pathways that caused the mitochondrial membrane to swell, increasing its permeability and allowing the leak of chemical signals that trigger apoptosis. sciencedaily/releases/2014/04/140404140213.htm
Posted on: Sat, 05 Apr 2014 16:49:36 +0000
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