Could neurodevelopmental disorders be a product of mistimed - TopicsExpress

Could neurodevelopmental disorders be a product of mistimed maturation of neural stem cells? It is a question posed (and published yesterday!) by researchers from McGill University. They propose the idea that maybe a transcription factor (TCF4) and specific histone-modifying enzyme (EHMT1) related to two distinct but overlapping neurodevelopmental disorders could be molecular targets worth attention. They modeled differentially mutated neural stem cells and found similarities between the two, notably in DNA methylation patterns, miRNA, and cellular characteristics reflective of rushed cell specialization. Because autism spectrum disorders are not often connected by the same genetic mutations, researchers are hoping that the molecular pathways related to the timing of cell specialization can be observed, targeted, and linked to other distinct but autism-associated genes. They hope to compare molecular convergence to other overlapping disorders in the future. “Our study suggests that one fundamental cause of disease is that neural stem cells choose to become more mature brain cells too early,” Ernst says. “This could affect how they incorporate into cellular networks, for example, leading to the clinical symptoms that we can see in kids with these diseases.” Contribution by BDK Gratreak, Science Officer

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