Curr Rheumatol Rev. 2015 Jan 13. [Epub ahead of print] Anti-Cyclic Citrullinated Peptide Antibodies as a Predictor of Clinical and Radiological Disease Severity in Rheumatoid Arthritis. M Kaushik R1. Abstract Materials and Methods- Fifty patients diagnosed as having RA as per 2010 revised ACR /EULAR classification criteria were included in this cross-sectional study. Serum ACPA, erythrocyte sedimentation rate (ESR), C-reactive protein, rheumatoid factor (RF), disease activity score with 28-joint counts (DAS28), visual analogue scale (VAS) for global disease activity, modified health assessment questionnaire score (M-HAQ) and radiological damage in hands and feet (modified Larsen score) were determined. Results- ACPA was positive in 48 (96%) and RF in 44 (88%) patients. Mean Larsen score was 19.82 ± 17.11 and mean DAS28 6.93 ± 1.6. A significant correlation of ACPA was seen with RF (p= 0.03) and Larsen score (p=0.02) but not with DAS28 (p=0.17) and M-HAQ (p=0.81). A significant correlation was seen between Larsen score and disease duration (p
Posted on: Thu, 22 Jan 2015 23:18:39 +0000
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