Dear Supporters: There is an opportunity for us to expand WFND’S current therapy program for PALS (People with ALS) and to totally stop ALS progression. Although not a cure, this new therapy will buy PALS time until a cure is found. By expanding the current therapy regimen to include another supplement, we believe research will prove that beginning this therapy will stop the disease in its tracks. The problem is the supplement in question, glutamate oxaloacetic transaminase (GOT), does not exist for human consumption. Please take a moment to read this letter to better understand the importance of an updated therapy program to include GOT and the Deanna Protocol™(DP), and to see how you can help. The Deanna Protocol™, which is part of the WFND Program for ALS, supplies energy to cells to keep them from dying. This has been proven via anecdotal evidence from PALS, and via mouse studies. When the cells die, they release glutamate into the extracellular space, which kills the contiguous cells. If we can supply enough energy to the PALS to stop the cells from dying, we can prolong their lives. However, if too many cells are dying, we cannot keep up with the cell death by supplying energy alone. Therefore, it is imperative that we neutralize the glutamate. Research already done at the Weizmann Institute in Israel has found a method to neutralize glutamate using GOT and hence, stopping the spread of ALS. There is enough anecdotal and research evidence indicating that the combination approach of the DP and GOT will totally stop the progression of ALS. There is a supplement, oxaloacetate, currently on the market that neutralizes glutamate, but it is extremely short lived in circulation and not nearly as effective as GOT. At this time, GOT is only made for research and not for human consumption. WFND has funded a research study on ALS mice, which will test the combination of the DP plus GOT to determine if the results are superior to using only the DP. Based on previously performed research on the DP and GOT, individually, we foresee a positive result where these substances will work together to stop ALS. We need funds in order to partner with an investigational pharmacology department at a university or perhaps a pharmaceutical company to make GOT for human consumption. Since GOT, like the DP, is a naturally occurring substance, we may not be able to raise the interest of a pharmaceutical company concerned about a return on investment. Once GOT is available for human consumption, we intend to conduct a clinical trial, which we fully expect to result in the cessation of ALS progression. A holding action until a cure can be found. We are the only non profit foundation whose research is based on cellular metabolism. We are the only non profit foundation whose research is working with substances normally found in the body. We are also the only entity, which has proven it can offer an effective therapy to slow the progression of ALS. All other research, currently in progress, is based on finding a pharmaceutical drug to cure ALS. This is important. This is necessary, but it will NOT help those currently fighting ALS as time is of the essence, and drug trials can take years. We are outside the mainstream of neurology, and we have neither received nor do we expect to be offered funds from the National Institutes of Health or the ALS Association. None of the $110 million and counting that the ALS Association collected from the ice bucket challenge will be awarded to us. I plan to donate $10,000 to fund this research, but that is not enough. I am asking for donations in any amount to help fund the production of GOT for human consumption and in turn, it will give PALS the hope of stopping ALS NOW. Donations may be made by going to winningthefight.org and clicking the donate button on the left side of the page. You may also mail checks payable to Winning the Fight to the address listed below. Donations are tax deductible to the fullest extent allowed by law. Please, give what you can. Please, give generously and give in honor of the PALS in your life. Give so that no one will ever have to give in memory again. Give for the honor of knowing that one day you can say YOU helped fund the treatment that stopped ALS and that together we did win the fight. Sincerely, Vincent M. Tedone Vincent M. Tedone MD FAAOS
Posted on: Fri, 19 Dec 2014 21:37:27 +0000
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