Definitions Disconnection A retrosynthetic step involving the - TopicsExpress



          

Definitions Disconnection A retrosynthetic step involving the breaking of a bond to form two (or more) synthons. Reterosyntis is a backword reactions. [ clarification needed ] Retron A minimal molecular substructure that enables certain transformations. Retrosynthetic tree A directed acyclic graph of several (or all) possible retrosyntheses of a single target. Synthon An idealized molecular fragment. A synthon and the corresponding commercially available synthetic equivalent are shown below: Target The desired final compound. Transform The reverse of a synthetic reaction; the formation of starting materials from a single product. Example An example will allow the concept of retrosynthetic analysis to be easily understood. In planning the synthesis of phenylacetic acid , two synthons are identified. A nucleophilic - COOH group, and an electrophilic PhCH 2 + group. Of course, both synthons do not exist per se; synthetic equivalents corresponding to the synthons are reacted to produce the desired product. In this case, the cyanide anion is the synthetic equivalent for the - COOH synthon, while benzyl bromide is the synthetic equivalent for the benzyl synthon.
Posted on: Sat, 01 Nov 2014 14:08:21 +0000

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