Dopamine Replacement Therapy Associated with Increase in Impulse Control Disorders Among Early Parkinson’s Disease Patients New Penn Medicine research shows that neuropsychiatric symptoms such as depression, anxiety and fatigue are more common in newly diagnosed Parkinson’s disease (PD) patients compared to the general population. The study also found that initiation of dopamine replacement therapy, the most common treatment for PD, was associated with increasing frequency of impulse control disorders and excessive daytime sleepiness. The new findings, the first longitudinal study to come out of the Parkinson’s Progression Markers Initiative (PPMI), are published in the August 15, 2014, issue of Neurology. The research is in Neurology. (full access paywall) Research: “Naltrexone for impulse control disorders in Parkinson disease: A placebo-controlled study” by Kimberly Papay, Sharon X. Xie, Matthew Stern, Howard Hurtig, Andrew Siderowf, John E. Duda, James Minger, and Daniel Weintraub in Neurology. doi:10.1212/WNL.0000000000000729 Image: Researchers found evidence that depression may be undertreated in early PD patients. Two-thirds of patients who screened positive for depression at any time point were not taking an antidepressant. The image is for illustrative purposes and is not connected to the research. The image shows two brain scans. Localization of the area of significant brain volume reduction in initial PD compared with a group of participants without the disease in a neuroimaging study, which concluded that brain stem damage may be the first identifiable stage of PD neuropathology. Credit Jubault et al./PLOS ONE. #Parkinsons #psychology #neurology
Posted on: Fri, 15 Aug 2014 20:23:19 +0000
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