#Dr_wessam_nounou O:) دكتورة O:) #Januvia & #Galvus من ادوية السكر المشهورة لكن بيشتغلوا ازاى ؟؟؟؟؟؟ للاجابة لازم نكون عارفين ( الصورة موضحة باختصار شديد ) الهدف من الادويه وجود ال :) incretin (GLP-1 & GIP) :D اطول وقت ممكن فى الجسم ومنع تكسيره بسرعه لانه مهم جدااااااا فى ضبط نسبة السكر بعدة طرق لكن المشكلة ان هناك انزيم اسمه DPP-4 يكسر ال incretin لذا نستخدم حاجه تمنع ال DPP-4 #Dipeptidyl_peptidase_4 inhibitor (DPP-4 inhibitors) and #GLP-1 #DPP-4 inhibitors or #gliptins, are a class of oral hypoglycemics that block DPP-4. They can be used to treat diabetes mellitus type 2. :) :) The mechanism of DPP-4 inhibitors is to increase incretin levels (GLP-1 and GIP) which :) inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels. ex: :D :D #Sitagliptin[5] (FDA approved 2006, ex: :( #Januvia), #Vildagliptin[6] (EU approved 2007, ex: :( #Galvus) #Sitagliptin is a DPP-4 inhibitor, which is believed to exert its actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones. Concentrations of the active intact hormones are increased by JANUVIA, thereby increasing and prolonging the action of these hormones. #Incretin_hormones, including glucagon-like peptide-1 (#GLP-1) and glucose-dependent insulinotropic polypeptide (#GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. These hormones are rapidly inactivated by the enzyme, #DPP-4. The incretins are part of an endogenous system involved in the physiologic regulation of glucose homeostasis. When blood glucose concentrations are normal or elevated, #GLP-1 and #GIP :) increase #insulin_synthesis and release from pancreatic beta cells by intracellular signaling pathways involving cyclic AMP. #GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to reduced hepatic glucose production. By increasing and prolonging active incretin levels, #JANUVIA increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner. en.wikipedia.org/wiki/Dipeptidyl_peptidase-4_inhibitor rxlist/januvia-drug/clinical-pharmacology.htm
Posted on: Sun, 16 Nov 2014 22:27:48 +0000
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