Endothelial dysfunction leads to impaired vasodilation and coagulation Description of study implications: "Prostacyclin (or PGI2), also known as known as eicosanoids, a member of the family prostaglandins as a metabolite of arachidonic acid, inhibits platelet aggregation, and dilates blood vessels and is released by healthy endothelial cells and performs its function through a paracrine signaling cascade that involves G protein-coupled receptors on nearby platelets and endothelial cells(a) Endothelial dysfunction and coagulation In the study to review endothelial properties and to establish how these unperturbed properties contribute to the maintenance of endothelium anticoagulant activity and to better understand the relative contributions of endothelial cells and monocytes in sepsis-induced altered coagulation, showed that Unperturbed endothelial cells provide anticoagulant properties; exposure to inflammatory and/or septic stimuli can rapidly lead to procoagulant behavior. Sepsis alters endothelial cell surface and induces tissue factor synthesis at the endothelial and subendothelial levels. During endotoxemia, endothelial cells generate adhesion molecules that bind leukocytes and monocytes, increasing local procoagulant reactions. Tissue factor expression is also increased at the level of the monocyte; the relative importance of endothelial injury and monocyte activation in coagulation disorders was recently assessed. Endothelium protection before induction of septic shock was not associated with any reduction in monocyte tissue factor expression, suggesting that altered coagulation was present despite normal endothelial cell function. On the other hand, decreased monocyte tissue factor expression was associated with a marked reduction in endothelial injury, increased endothelium-derived relaxation, and improved survival rate in treated animals(18). Sources (a) en.wikipedia.org/wiki/Prostacyclin . (18) ncbi.nlm.nih.gov/pubmed/11445732" Source for this description of study: medicaladvisorjournals.blogspot.ca/2013/05/endothelial-dysfunction-and-coagulation.html?zx=d8f63953bf030e87
Posted on: Fri, 02 Aug 2013 20:21:58 +0000
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