Estriol(E3) is the “safe estrogen.” It is the key to estrogen balance and breast cancer prevention. Estriol selectively binds to estrogen receptor-beta (ER-beta), which inhibits breast cell proliferation and prevents breast cancer development. (Source: Postgraduate medicine, Vol 121, Issue 1, January 2009; Endocrinology. 2006 Sep;147(9):4132-50. Epub 2006 May 25.) Estradiol (E2), on the other hand, activates the cancer activating protein known as bcl-2, which promotes cancer cell growth and decreases Tumor Suppressor Protein (known as p53), which is one of the body’s primary cancer prevention mechanisms. (Source: Ann Clin Lab Sci. 1998 Nov-Dec;28(6):360-9; Int J Cancer. 2003 Jul 10;105(5):607-12) Estriol (E3) produces a 30% reduced risk of breast cancer; Estradiol (E2) causes a 10% increased risk of breast cancer. (Source: Fournier et al, “Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort,” Int J Cancer 2005 Apr 10;114(3):448-54.)
Posted on: Sun, 16 Jun 2013 22:38:13 +0000
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