HIGH DOSES OF B VITAMINS INCREASE THE RISK OF KIDNEY DISEASE, MYOCARDIAL INFARCTION AND STROKE In conclusion, in our randomized trial of participants with diabetic nephropathy and stages 1 to 3 chronic kidney disease, the use of high doses of B vitamins (containing 2.5 mg/d of folic acid, 25 mg/d of vitamin B6, and 1 mg/d of vitamin B12) compared with placebo resulted in a greater decrease in GFR and an increase in MI and stroke. Given the recent large-scale clinical trials showing no treatment benefit, and our trial demonstrating harm, it would be prudent to discourage the use of high-dose B vitamins as a homocysteine-lowering strategy outside the framework of properly conducted clinical research.
Posted on: Fri, 21 Jun 2013 17:27:59 +0000
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