Hasta 1859, cuando Albert Niemann aisló la cocaína de la hoja de - TopicsExpress

Hasta 1859, cuando Albert Niemann aisló la cocaína de la hoja de coca, el consumo no era notable fuera de América, pues el complicado transporte de las hojas generaba la pérdida de los principios activos. Con la mejora del embalaje del producto y con el aislamiento de su principio activo, la cocaína empezó a ganar espacio entre los consumidores europeos. Los laboratorios (Merck y Parke Davis) aislaban la cocaína en América y transportaban el producto en bruto. En 1863, un farmacéutico francés, Angelo Mariani, creó un preparado de extracto de coca y vino (Vino Mariano) que tuvo gran éxito comercial como bebida tonificante

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