Home Food Science & Research (Food) Risk & Safety Assessment Science & Research (Food) Risk & Safety Assessment - Listeria monocytogenes Risk Assessment: IV. Hazard Characterization FDA/Center for Food Safety and Applied Nutrition USDA/Food Safety and Inspection Service September 2003 Contents Dose-Response Modeling Comparison of the FDA/FSIS Revised Dose-Response Model to Other Dose-Response Models for Listeria monocytogenes Dose-Response in Animal Surrogates Data Collected from Animal Studies Modeling: Dose-Response in Mice Dose-Response Curves for Infection and Serious Illness Variability in Virulence Host Susceptibility Modeling: Host Susceptibility Dose-Response Scaling Factor Results: Dose-Response Curves for Three Population Groups Hazard characterization describes the adverse effects of a particular substance, organism, or other entity. The relationship between the exposure level (dose) and frequency of illness or other adverse effect (response) is estimated and the severity of the health effects is also evaluated, often by considering multiple biological endpoints (e.g., infection, morbidity, fatalities, sequelae). In the case of Listeria monocytogenes, the overall incidence of illness, its severity, and the differential risk to immunocompromised subpopulations are well characterized (see section titled "II: Hazard Identification"). In contrast, the relationship between the amount of Listeria monocytogenes consumed (the dose) and the likelihood or severity of illness resulting from that dose (the response) is not well understood. This part of the Listeria monocytogenes risk assessment focuses on characterization of the dose-response relationship.
Posted on: Thu, 20 Jun 2013 19:01:34 +0000
Trending Topics
Recently Viewed Topics
© 2015