I just got this email in response to my query to Juice Plus about whether the FOLIC ACID listed on the label was indeed synthetic or was it actually whole food folate, since that is what they promote. Im at a loss... Hello Erica, We are happy to assist you with this. There is unfortunately much misinformation about the mutation that you have. If you look at how the folate metabolism works (see this diagram for reference nchpeg.org/nutrition/index.php?option=com_content&view=article&id=452&tmpl=component) you will notice that dietary folate (and folic acid as well) get immediately methylated by the body to be absorbed. The resulting compound, methyltetrahydrofolate is then metabolized into tetrahydrofolate (THF) and then to 5, 10 methylene tetrahydrofolate. On healthy people, that compound is then reduced by the enzyme methylenetetrahydrofolate reductase (MTHFR) back to methyl tetrahydrofolate. Sorry about getting too technical on you, you can forget about the names if you want to but simply notice where the MTHFR enzyme plays a role. If there is not enough of the enzyme MTHFR to effect this reaction, the only other source is both folate and folic acid from the diet. It is a very common misunderstanding about folate and folic acid metabolism, but both can be metabolized by people with the MTHFR mutation. By the way, this diagram also illustrates the fallacy of using “methylated folate”, an extremely expensive product of folic acid, which as you can see, our body manufactures from both folate and folic acid and has nothing to do with the genetic mutation. Thank you, Juice Plus+® Customer Care 140 Crescent Drive Collierville, TN 38017 PHONE (800) 347-6350 FAX (901) 850-3061
Posted on: Tue, 16 Sep 2014 22:48:06 +0000
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