ICU Roomより。 Q: On which day after initiation of empiric antibiotic therapy, de-escalation should be considered? 質問：empiric抗生剤治療を開始後何日でde-escalationを行うべきだろうか？ Answer: 3 - 5 days For patients who have suspicion of infection, early and appropriate therapy - and probably aggressive empirical therapy - is required at the first sign of infection. Although, the initial choice of antimicrobial therapy is critical to the clinical outcomes of patients, it is also imperative to start de-escalation of antibiotics therapy as emerging data is showing benefit in mortality rate, or at least no worse out come. De-escalation therapy based on APACHE II score can be safely applied with good clinical outcomes, even in those patients with negative cultures.
Posted on: Sun, 05 Oct 2014 02:08:44 +0000
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