¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤ IgA Nephropathy is sometimes called Bergers disease as a French doctor, Jean Berger, was the first to describe it. Nephropathy simply means kidney disease. The antibody IgA (Immunoglobulin A), derived from the lining of the throat, air passages and intestine is found in the kidney and has caused damage to the kidney. The most prevalent antibody defect is a selective IgA deficiency (SIgAD). Alterations in IgA1/IgA2 ratio very often go hand in hand with specific disease states such as recurring infections of the airways or a kidney disorder called IgA nephropathy. There are various severe health conditions that can lead to low levels of Immunoglobulin A in the body such as gonorrhea. The bacteria leading to gonorrhea produce an enzyme leading to the splicing of IgA antibodies into the Fc and Fab fragment. The Fab part still can recognize the bacteria, but without the Fc fragment, attachment to phagocyting cells is not possible. When the body does not have sufficient quantities of IgA, the person may be diagnosed with selective IgA deficiency. Patients suffering from selective Immunoglobulin A deficiency can have normal levels of the other antibodies, fully functioning T-cells, phagocytes, and other components of the immune system. Patients who suffer from a selective IgA deficiency are more prone to autoimmune disorders are more prone to autoimmune disorders like Rheumatoid Arthritis, Lupus, allergies and asthma. ¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤¤
Posted on: Sat, 15 Mar 2014 08:32:47 +0000
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