KEY POINTS: SICKLE CELL DISEASE 1. A genetic mutation leads to an - TopicsExpress

KEY POINTS: SICKLE CELL DISEASE 1. A genetic mutation leads to an abnormalb-globin chain. 2. Eight percent of African Americans have the sickle cell trait. 3. Crises include vaso-occlusive, sequestration, and aplastic. 4. The risk for serious bacterial infection is increased among these patients as a result of functional asplenia. 5. Dactylitis (painful hand and foot swelling) is often the earliest manifestation.

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