Long-term effects of inhaled nicotine. Department of Medicine, University Hospital, Tronheim, Norway. Conclusie: For the first time we report the effect on the rat of long-term (two years) inhalation of nicotine. The rats breathed in a chamber with nicotine at a concentration giving twice the plasma concentration found in heavy smokers. Nicotine was given for 20 h a day, five days a week during a two-year period. We could not find any increase in mortality, in atherosclerosis or frequency of tumors in these rats compared with controls. Particularly, there was no microscopic or macroscopic lung tumors nor any increase in pulmonary neuroendocrine cells. Bron: ncbi.nlm.nih.gov/pubmed/8614291
Posted on: Mon, 25 Nov 2013 21:19:38 +0000
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