Macrophages infected with bacillus anthracis Anthrax is a - TopicsExpress

Macrophages infected with bacillus anthracis Anthrax is a toxigenic bacterium that produces a complex, three-component toxin protective antigen (PA) binds the host cell and translocates edema factor (EF) and lethal factor (LF) into the cytoplasm EF increases the intracellular concentration of an important signaling molecule called cAMP, which disrupts water balance and cellular function LF also alters signaling pathways but this disrupts macrophage function to ultimately cause apoptosis interestingly, if any of these three components is individually injected into an animal, there is no effect: without PA, LF and EF cannot enter the cell SEM credit: Max Planck Institute for Infection Biology

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