Memantine： • Glutamatergic (NMDA receptor) Memantine is a - TopicsExpress

Memantine： • Glutamatergic (NMDA receptor) Memantine is a low-affinity voltage-dependent uncompetitive antagonist at glutamatergic NMDA receptors. • Serotonergic (5-HT3receptor) Memantine acts as a non-competitive antagonist at the 5-HT3 receptor, with a potency similar to that for the NMDA receptor. • Cholinergic (nicotinic acetylcholine receptor) Memantine acts as a non-competitive antagonist at different neuronal nicotinic acetylcholine receptors(nAChRs). • Dopaminergic (D2 receptor) Memantine acts as an agonist at the dopamine D2 receptor. onlinelibrary.wiley/doi/10.1002/gps.4109/abstract?campaign=woletoc

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