NERD. God I love this stuff. schizophreniabulletin.oxfordjournals.org/content/36/6/1061.short Toward New Approaches to Psychotic Disorders: The NIMH Research Domain Criteria Project These are interesting times for schizophrenia research. Among the many exciting signs of progress, recent genome-wide association study (GWAS) reports have attracted considerable attention for their unexpected findings. While many genetic factors have been identified to date by GWAS and other case-control studies, in aggregate, these factors have accounted for only a small percentage of the reported heritability of the disorder. Perhaps the most unexpected finding has been the growing recognition that nearly all genetic factors identified thus far, whether common allelic variants or rare structural variants, seem to confer somewhat comparable risk for schizophrenia and bipolar disorder and, perhaps, for other disorders such as unipolar depression, substance abuse, and even epilepsy.1–3 These are only examples of numerous recent studies suggesting that the biology of psychotic illnesses may fail to align neatly with the classic Kraepelinian distinction between schizophrenia and manic-depressive illness that has served clinical practice and research for well over a century. However, they do resonate with clinical observations that many patients present with a mix of bipolar and schizophrenia symptoms, both at a single admission and also across time. These clinical observations support the accelerating body of literature over the last decade arguing that Kraepelin’s classic dichotomy for psychotic disorders may need to be superseded by a new system based on biology as well as observed clinical phenomenology.
Posted on: Wed, 03 Dec 2014 05:58:37 +0000
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