Nanomolar aluminum induces pro-inflammatory and pro-apoptotic gene expression in human brain cells in primary culture Walter J. Lukiw a,*, Maire E. Percy b, Theo P. Kruck b a Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8B8, New Orleans, LA 70112-2272, USA b Neurogenetics Laboratories, Surrey Place Center and Center for Research in Neurodegenerative Disease, Tanz Neuroscience Center, University of Toronto, Toronto, Ont., Canada M5S 1A8 Received 23 March 2005; received in revised form 19 April 2005; accepted 20 April 2005 Excerpt: The promoters of genes up-regulated by aluminum are enriched in binding sites for the stress-inducible transcription factors HIF-1 and NF-kappaB, suggesting a role for aluminum, HIF-1 and NF-kappaB in driving atypical, pro-inflammatory and pro-apoptotic gene expression. The effect of aluminum on specific stress-related gene expression patterns in human brain cells clearly warrant further investigation. sciencedirect/science/article/pii/S0162013405001182 ncbi.nlm.nih.gov/pubmed/15961160
Posted on: Sun, 07 Jul 2013 06:43:53 +0000