PATHOPHYSIOLOGY OF EBOLA VIRUS. Patho mean disease,physiology - TopicsExpress

PATHOPHYSIOLOGY OF EBOLA VIRUS. Patho mean disease,physiology is talk about functions of the body.This implies how the disease affect the functions of the body. Endothelial cells,mononuclear phagocytes,and hepatocytes are the main target of infection.After infection,a secreted glycoprotein (s G P) know as the ebola virus glycoprotein (GP) is synthesized,ebola replication overwhelms protein synthesis of infected cells and host immune defense.The presence of viral particles and cell damages resulting from budding causes the release of cytokines,which are the signaling molecules of fever and inflammation.The G P forms a trimetric complex,which binds the virus to the skin layer know as the endothelial cells lining the interior surface of d blood vessels,making it loss its vascular integrity,this to bleeding.

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