Part II In article, Clinical Immunology Unit of Santa Casa – Rio de Janeiro- UIC. Brazil and the Universidade Federal do Rio de Janeiro-UFRJ FotoImunoDermatologia Sector, published in 2014, in the British medical journal, Dermatologic Therapy, ratified the immunoregulatory action on cutaneous lymphomas, demonstrating the use of ultraviolet therapy. Other diseases that respond to ultraviolet therapy is scleroderma, urticaria pigmentosa, atopic dermatitis, graft versus host disease, dyshidrosis and even systemic lupus erythematosus, hypereosinophilic syndrome, Liquem scleroatrophic, sarcoidosis, psoriasis and chronic urticaria. However, must be clear that use of ultraviolet radiation for therapy, is not exposure to natural sunlight, on your own. Should be conducted in special chambers and only by the doctor who thoroughly understands this kind of treatment. The therapy uses a specific part of the curative ultraviolet radiation. The consequence of VIT D deficiency is associated with bone changes. In VITD deficiency, calcium absorption cannot be increased enough to meet the needs of the organism thus will remove calcium from bone to blood to maintain normal serum levels. Vit D deficiency is also associated with the development of immune system diseases, autoimmune diseases, multiple sclerosis, rheumatoid arthritis, and allergic dermatitis. Exposure of limbs 2 times week by 5-30 minutes can enough producing VITD required. The major argument is the action of ultraviolet radiation is an inducer of inflammation of epidermis and the formation of free radicals by the cells of the epidermis, especially when there is a solar erythema, redness. The free radicals harm DNA. Thus, there are almost four hundred types of DNA repair enzymes, but at this point is that there may be the wrong repair, mutation, and consequent induction of skin cancer. These free radicals are also related to the destruction of the elastic fibers of the skin, leading to premature aging, premature senescence. Moreover, free radicals kill cells by a mechanism known as death induced, apoptosis. After this mechanism of cell death, there is induction of cells and fibers proliferation leading to thickening of the cutaneous tissue, as seen in the fishermen, farmers and those people exposed to intense sun on unprotected manner. Therefore, redness induced by solar radiation, never. The tanning induced by ultraviolet radiation, which results from melanocytes protein production, the melanin, in the skin; possess scavenging free radicals activity as well as physiological solar protective action. The question is how to produce VITD with sun exposure, tanning, with no photoaging and thickening skin, and mainly without inducing skin cancer.
Posted on: Sat, 08 Mar 2014 15:26:19 +0000
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