Protandim From Wikipedia, the free encyclopedia LifeVantage Type Public Traded as NASDAQ: LFVN Industry Nutrition, Skin Care products Founded 2003 Headquarters Salt Lake City, Utah, United States Area served United States, Canada, Japan, Mexico, Australia, Hong Kong Key people Douglas C. Robinson, Robert M. Urban, Shawn M. Talbott, David Toda, Kirby Zenger, David Colbert, David W. Brown, Joe M. McCord (retired) Products Protandim, TrueScience, Canine Health Revenue US$ 208.2 million [1] Operating income US$ 12.1 million Website LifeVantage Protandim is a patented[2] dietary supplement marketed by LifeVantage Corporation (NASDAQ: LFVN; formerly LifeLine Therapeutics, Lifeline Nutraceuticals, and Yaak River Resources, Inc), a Utah-based multilevel marketing company.[3] The manufacturers of Protandim claim the product can indirectly increase antioxidant activity by upregulating endogenous antioxidant factors such as the enzymes superoxide dismutase (SOD) and catalase, as well as the tripeptide glutathione. Like all dietary supplements, Protandim has not been evaluated by the U.S. Food and Drug Administration (FDA) and is not intended to diagnose, treat, cure, or prevent any disease.[4] Contents [hide] 1 Product history 1.1 Voluntary recall 2 Composition 3 Side effects 4 Research 4.1 Overview 4.2 Human clinical studies 4.3 In vitro and animal studies 5 Legal issues 6 Advertising and sponsorship 7 Product development 8 References 9 External links Product history[edit] In 2003, Lifeline Therapeutics, a privately held Denver-based nutraceutical licensing and marketing company, entered into a joint agreement with Massachusetts biotechnology company CereMedix for the rights to market CMX-1152, an experimental peptide-based compound, under the brand name Protandim (also sometimes referred to at that time as Rholen, Rejuven8r and ependymin).[5][6][7][8][9][10][11] CereMedix was a ten percent owner of Lifeline and members of the CereMedix management board served on Lifeline’s board of directors. CMX-1152 was claimed to upregulate the production of the endogenous antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase, and to offset the ageing process, potentially allowing people to live up to the age of 120.[10] CMX-1152 was due to be marketed as an over the counter anti-aging pill in June 2004 after completing human clinical trials. However, plans to market the CMX-1152 version of Protandim fell through and in April 2004 Lifeline Therapeutics announced that it would instead be marketing a different (non-peptide) dietary supplement under the name “Protandim CF” (to distinguish it from the peptide version initially developed by Cermedix). The new version of Protandim, a combination of 5 common herbal ingredients including turmeric and green tea was invented following “months of extensive research and development” by Lifeline employees Paul Myhill and William Driscoll (a former oil company executive), who together hold the patent on the product,[2] and it was officially launched in February 2005. Myhill and Driscoll resigned from the company later that year.[11][12][13][14] Like CMX-1152, the herbal version of Protandim that supplanted it was marketed by Lifeline as an anti-aging supplement that increases the body’s antioxidant defenses by upregulating superoxide dismutase, catalase, and glutathione peroxidase. According to the company, the product was initially sold through retail channels such as GNC;[15] however, in 2009, after several consecutive years of multimillion dollar losses, the company, which by then was doing business under the name LifeVantage, stopped marketing Protandim through retailers and switched to multilevel marketing, selling it instead through a network of commissioned independent distributors exclusively. According to LifeVantage, the move from retail to multi-level marketing was prompted by the January 2008 hiring of David W. Brown, (formerly CEO and president of Metabolife) as the companys CEO and president.[16][17] Beginning in 2005, Protandim was produced under a manufacturing agreement with The Chemins Company of Colorado Springs, Colorado.[18] In July 2008, LifeVantage entered into a new manufacturing agreement with Cornerstone Research & Development to produce Protandim, and with Wasatch Product Development to produce a Protandim-based skin cream (TrueScience).[19] Voluntary recall[edit] In December 2012, LifeVantage issued a voluntary recall of select lots (10 lots in total comprising 247,896 bottles) of Protandim due to potential health risks arising from the possible inclusion of small metal fragments in the final product.[20][21] In February 2013, the company announced that it was extending the recall to include additional lots of the product, estimating the total cost of the recall at $5.9 million.[22] Composition[edit] Protandim consists mainly of a blend of 5 herbal ingredients (amounts per caplet listed in parentheses): Milk thistle (Silybum marianum) extract (225 mg) Bacopa (Bacopa monniera) extract (150 mg) Ashwagandha (Withania somnifera) root (150 mg) Green tea (Camellia sinensis) extract (75 mg) Turmeric (Curcuma Ionga) extract (75 mg) Additional ingredients include: calcium, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, modified cellulose, silica, and stearic acid.[citation needed] Side effects[edit]
Posted on: Wed, 05 Mar 2014 04:21:46 +0000
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