Protandim article #1: Discussion This is the original article published in 2006 in the journal Free Radical Biology and Medicine. This study is a human trial that was performed at the University of Colorado. Blood (erythrocytes) was analyzed before the study, after 30 days, and 120 days. The revelant findings include: 1. a 40% average reduction in plasma TBARS (and indication of oxidative stress) after 30 days which continued to improve until baseline levels were reached. 2. erythrocyte levels of S.O.D. and Catalase increased by 30% and 54% respectively after 120 days. These findings have been confirmed now in 14 other clinical studies to date with similar findings reported. Of interest to me is why glutathione levels were not assessed during this study, however the question of glutathione has been answered in subsequent studies. Relevance Protandim decreases indicators of oxidative stress and increases the levels of protective antioxidants inside of our cells. This improvement reaches baseline, meaning the equivalent of a 20 year old or younger, within 120 days and continues to maintain as long as we are taking Protandim. This result has been reinforced clinically and in later independent studies over and over again. Free Radic Biol Med. 2006 Jan 15;40(2):341-7. The induction of human superoxide dismutase and catalase in vivo: a fundamentally new approach to antioxidant therapy. Nelson SK1, Bose SK, Grunwald GK, Myhill P, McCord JM. Abstract A composition consisting of extracts of five widely studied medicinal plants (Protandim) was administered to healthy human subjects ranging in age from 20 to 78 years. Individual ingredients were selected on the basis of published findings of induction of superoxide dismutase (SOD) and/or catalase in rodents in vivo, combined with evidence of decreasing lipid peroxidation. Each ingredient was present at a dosage sufficiently low to avoid any accompanying unwanted pharmacological effects. Blood was analyzed before supplementation and after 30 and 120 days of supplementation (675 mg/day). Erythrocytes were assayed for SOD and catalase, and plasma was assayed for lipid peroxidation products as thiobarbituric acid-reacting substances (TBARS), as well as uric acid, C-reactive protein, and cholesterol (total, LDL, and HDL). Before supplementation, TBARS showed a strong age-dependent increase. After 30 days of supplementation, TBARS declined by an average of 40% (p = 0.0001) and the age-dependent increase was eliminated. By 120 days, erythrocyte SOD increased by 30% (p < 0.01) and catalase by 54% (p < 0.002). We conclude that modest induction of the catalytic antioxidants SOD and catalase may be a much more effective approach than supplementation with antioxidants (such as vitamins C and E) that can, at best, stoichiometrically scavenge a very small fraction of total oxidant production. PMID: 16413416 [PubMed - indexed for MEDLINE]
Posted on: Sun, 25 Jan 2015 00:04:24 +0000
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