Reduction of Tau Protein Improves Symptoms in Model of Severe Childhood Epilepsy Researchers at the Gladstone Institutes have shown that reducing brain levels of the protein tau effectively blocks the development of disease in a mouse model of Dravet syndrome, a severe intractable form of childhood epilepsy. This therapeutic strategy not only suppressed seizure activity and premature death, but also improved cognitive and behavioral abnormalities that can accompany this syndrome.. The research is in Annals of Neurology, Science and Journal of Neuroscience. (full access paywall) Research: “Tau reduction prevents disease in a mouse model of Dravet syndrome” by Ania L. Gheyara, Ravikumar Ponnusamy, Biljana Djukic, Ryan J. Craft, Kaitlyn Ho, Weikun Guo, Mariel M. Finucane, Pascal E. Sanchez and Lennart Mucke in Annals of Neurology. doi:10.1002/ana.24230 “Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer’s Disease Mouse Model” by Erik D. Roberson, Kimberly Scearce-Levie, Jorge J. Palop, Fengrong Yan, Irene H. Cheng, Tiffany Wu, Hilary Gerstein, Gui-Qiu Yu, and Lennart Mucke in Science. doi:10.1126/science.1141736 “Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer’s Disease” by Erik D. Roberson, Brian Halabisky, Jong W. Yoo, Jinghua Yao, Jeannie Chin, Fengrong Yan, Tiffany Wu, Patricia Hamto, Nino Devidze, Gui-Qiu Yu, Jorge J. Palop, Jeffrey L. Noebels, and Lennart Mucke in Journal of Neuroscience. doi:10.1523/JNEUROSCI.4152-10.2011 Image: Researchers reduced the level of the protein tau by genetically engineering Dravet mouse models, “knocking out” the gene associated with tau production. This image is for illustrative purposes and is not connected to the research. Credit NIH/NIA. #neurology #neuroscience
Posted on: Wed, 13 Aug 2014 19:58:18 +0000
Trending Topics
Recently Viewed Topics
© 2015