Research from scientists from Brussels has confirmed that skin cancer is related directly to oxidative stress – and other research shows antioxidants reduce oxidative stress. The new research comes from the Brussels Central Hospital, University of Charleroi, and the Hospital Vesale Experimental Medicine Laboratory at Free University of Brussels. The researchers tested 36 patients with head and neck squamous cell carcinomas – one of the most lethal forms of skin cancer. The researchers collected the tumor tissues of the 36 patients along with close-by tissue without tumors. The researchers then conducted an indepth analysis of the tissues and tested them using capillary electrophoresis – testing that separates and breaks down tissues into their smaller components. The researchers also conducted oxidation testing and specifically determined the ratios between oxidized glutathione and reduced glutathione. The ratio of oxidized glutathione to reduced glutathione in the tissues relates directly to the amount of oxidative stress in the tissues, as well as indicates the level of antioxidant activity. This is because glutathione is the leading scavenger of oxidation within the body. The researchers found that the tumor tissues showed significantly higher variation in the glutathione GSH part of the ratio. This indicates that the free scavenging abilities of glutathione are reduced within skin cancer tissue.
Posted on: Thu, 07 Nov 2013 19:17:36 +0000
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