Sesamol, a nutral constituent of sesame seed could provide relief to arthritis sufferers. A paper in the latest issue of the European Journal of Nutrition says: Sesamol has anti-arthritic, anti-inflammatory, anti-oxidative stress and chondro-protective potentials of sesamol in vivo. The scientists had used a standard rodent model of arthritic pain and administered Sesamol in dosagaes of either 25 or 50 mg/kg. Compared to the 10 mg/mg control group the rats in the sesamol group experienced less swelling. The scientists also observed # reduced cartilage degeneration (by mitigating augmented serum levels of hyaluronidase and matrix metalloproteinases, MP-13, MMP-3 and MMP-9), # lowered bone resorption (=bone loss), # an abrogation of the non-enzymatic inflammatory markers (TNF, IL-1β, IL-6, COX-2, PGE2, ROS, and H2O2), and # a restoration of the ROS levels, lipid and hydro peroxides and sustained antioxidant homeostasis by re-establishing altered activities of superoxide dismutase, catalase and glutathione-s-transferase The effects were indeed so (all-)encompassing that the researchers from the University of Mysore in India argue: "[S]esamol could be a single bullet that can fight arthritis as well as the secondary complications of arthritis such as cardio vascular disorders and diabetes." suppversity Reference: Hemshekhar M, Thushara RM, Jnaneshwari S, Devaraja S, Kemparaju K, Girish KS. Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status. Eur J Nutr. 2013 Oct;52(7):1787-99.
Posted on: Mon, 30 Sep 2013 05:13:45 +0000
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