Some human milk oligosaccharides—simple sugar carbohydrates—were recently discovered to be indigestible by infants. When my son was nursing, those oligosaccharides weren’t meant for him. They were meant for bacteria in his gut, which thought they were delicious. My wife was, in a sense, nursing another species altogether, a species that had been evolutionarily selected to protect her child. (A relationship immortalized in the paper titled “Human Milk Oligosaccharides: Every Baby Needs a Sugar Mama.”) In effect, as Hinde and UC-Davis chemist Bruce German have written, “mothers are not just eating for two, they are actually eating for 2 × 1011 (their own intestinal microbiome as well as their infant’s)!” That’s what’s meant by milk serving as medicine, and that’s only scratching the surface. But Hinde primarily studies the food and the signal elements of milk. “The signal is in the form of hormones that are exerting physiological effects in the infant,” she explains. “Infants have their own internal hormones, but they’re also getting hormones from their mother. They’re binding to receptors in the babies, and we’re just starting to understand what those effects are.” Hinde works with rhesus macaques, and she’s tracked the effects of the hormone cortisol in their milk. Cortisol is often thought of as the stress hormone, but its function is far more varied, and Hinde has found that the amount and especially the variation of cortisol successfully predicts how the infant macaques go on to behave. It’s a stunning finding: The composition of early milk seems to mold infant temperament. But—and here’s the twist—the males were much more sensitive than the females. Roughly, the more cortisol, the more bold and exploratory the male rhesus macaques were.
Posted on: Tue, 03 Dec 2013 06:57:44 +0000