THANK YOU SPAIN...glad to know someone is watching out for us.... The role of prion protein in stem cell regulation. ncbi.nlm.nih.gov/pubmed/23740082 Reproduction. 2013 Jun 5. [Epub ahead of print] Miranda A, Ramos-Ibeas P, Pericuesta E, Ramirez MA, Gutierrez-Adan A. Source A Miranda, Animal Reproduction, INIA, Madrid, Spain. Abstract Cellular Prion Protein (PrPC) has been well described as an essential partner of prion diseases due to the existence of a pathological conformation (PrPSc). Recently, it was also demonstrated that PrPC is an important element of the pluripotency and self-renewal matrix, with an increasing amount of evidence pointing in this direction. Here, we review the data which demonstrate its role in transcriptional regulation of pluripotency, in differentiation of stem cells into different lineages (e.g. muscle and neurons), in embryonic development, and its involvement in reproductive cells. Also highlighted are recent results from our laboratory which describe an important regulation by PrPC of the major pluripotency gene Nanog. Together, these data support the appearance of new strategies to control stemness which could represent an important advance in the field of regenerative medicine.
Posted on: Fri, 07 Jun 2013 22:44:19 +0000
Trending Topics
Recently Viewed Topics
© 2015