The data suggest that the anti-aging effects in the Snell dwarf and GHR-/- mice are accompanied by both a decline in mTORC1 in multiple organs and an increase in fasting levels of mTORC2. Neither the lifespan nor mTOR effects appear to be mediated by direct GH effects on liver or by the decline in plasma IGF-1, a shared trait in both global and liver-specific GHR-/- mice. Our data suggest that a more complex pattern of hormonal effects and inter-tissue interactions may be responsible for regulating both lifespan and mTORC2 function in these mouse models of delayed agingncbi.nlm.nih.gov/pubmed/25456069
Posted on: Wed, 03 Dec 2014 23:02:43 +0000
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