Treatment Trials for Post-Lyme Disease Symptoms Revisited. - TopicsExpress



          

Treatment Trials for Post-Lyme Disease Symptoms Revisited. Authors: Klempner MS, Baker PJ, Shapiro ED, Marques A, Dattwyler RJ, Halperin JJ, Wormser GP Citation: Am. J. Med. 2013(Jun) Location: University of Massachusetts Medical School, Boston. DOI: 10.1016/j.amjmed.2013.02.014 The authors of 4 National Institutes of Health-sponsored antibiotic treatment trials of patients with persistent unexplained symptoms despite previous antibiotic treatment of Lyme disease determined that retreatment provides little if any benefit and carries significant risk. Two groups recently provided an independent reassessment of these trials and concluded that prolonged courses of antibiotics are likely to be helpful. We have carefully considered the points raised by these groups, along with our own critical review of the treatment trials. On the basis of this analysis, the conclusion that there is a meaningful clinical benefit to be gained from retreatment of such patients with parenteral antibiotic therapy cannot be justified. Copyright © 2013 Elsevier Inc. All rights reserved. 10.1016/j.amjmed.2013.02.014
Posted on: Sun, 28 Jul 2013 21:28:16 +0000

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