"Until now, the recommended diet for the patient with CKD is traditionally based on protein and phosphorus restriction. Excessive fructose intake may also be carefully avoided by the patient with CKD to slow the progression of the disease. Besides renal degradation, we show here that not only mineral but also vitamin D homeostasis is markedly altered by excessive fructose consumption. The decrease in 25-(OH)D3 level indicates that liver function during ESRD is also compromised by fructose feeding. Further studies need to be conducted to evaluate whether the impairment of vitamin D synthesis by fructose is direct or is a secondary, indirect effect of the deleterious consequence of fructose on renal function. Dietary fructose constitutes approximately 60% of our rat diet, but the average fructose content of American diets is 15 to 17%; therefore, further studies need to be done using lower levels of dietary fructose and longer durations of feeding to evaluate properly the effect of this sugar on the progression and complications of CKD."
Posted on: Sat, 06 Jul 2013 08:00:53 +0000
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