Want sustainable weight loss without a life of dieting? METABOLIC FLEXIBILITY is the key to MORE MUSCLE and LESS FAT! Its the secret behind achieving your IDEAL BODY COMPOSITION while being able to eat a more balanced diet (and include a few indulgences without always paying for it!) Metabolic flexibility is the capacity for the body to adapt fuel oxidation to fuel availability. The inability to modify fuel oxidation in response to changes in nutrient availability has been implicated in the accumulation of excess fat stores and insulin resistance. The metabolic flexibility assessed by the ability to switch between fat and carbohydrate oxidation is usually impaired in those who struggle with weight loss; however, this “metabolic inflexibility” is mostly the consequence of impaired cellular glucose uptake. An impaired capacity to upregulate fat as fuel in the face of excess fat stores may lead to increased fat accumulation and insulin resistance. Just as one can condition their muscles to be more flexible, so too can we condition our metabolism! This is what happens during a program of nutritional cleansing which positively impacts insulin sensitivity and where the glucose disposal rate, adipose tissue lipid storage, and mitochondrial function all play roles on metabolic flexibility...creating a metabolism that is more flexible, efficient and responsive to dealing with the digestion and utilization of carbs, fats and protein. 1. Metabolic flexibility and insulin resistance. Am J Physiol Endocrinol Metab. Nov. 2008. 2. The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility. Nutrition Metabolism. 2014. 3. The therapeutic implications of ketone bodies: The effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 2004. 4. Effect of exercise training on metabolic flexibility in response to a high-fat diet in obese individuals. Am J Physiol. 2012.
Posted on: Sun, 07 Sep 2014 11:21:27 +0000
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